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There is something wrong with You are informing someone that there is something not right or out of the ordinary.

How come + (subject + verb) When using ‘how come’ you are asking why a particular thing has or had

Here’s to + (noun) ‘Here’s to’ is used in a way of celebrating or identifying a person, place, or thing

It takes + (time) + to + (verb) You are letting someone know how long it will take to do

Let’s say that + (subject + verb) ‘Let’s’ is a contraction for ‘let us.’ You are suggesting to someone that

There is something wrong with + (noun) You are informing someone that there is something not right or out of

By asking ‘what are the chances of’ you are wondering how often or in what case would a particular thing